Plasma levels of viro-immunological markers in HIV-infected and non -infected Ethiopians: Correlation with cell surface activation markers
| Id | EPHI-DS0121 |
|---|---|
| Name | Plasma levels of viro-immunological markers in HIV-infected and non -infected Ethiopians: Correlation with cell surface activation markers |
| Format | .dta |
| Coverage Location | Regional |
| Coverage Sex | Both |
| Abstract | These cross-sectional studies were conducted to measure soluble viral and immunological markers in plasma in order to determine the prognostic value of these markers for HIV disease progression in Ethiopians and to see their association with cell surface markers in HIV-1-infected and noninfected Ethiopians. Whole blood samples were collected from 52 HIV-1-negative Ethiopians, 32 HIV-1-positive Ethiopians with absolute CD41 T-cell count >200/ml whole blood and no AIDS-defining conditions, and 39 HIV-positive Ethiopians with CD41 T-cell count <200/ml and/or AIDS-defining conditions. Plasma levels of b2-microglobulin (b2m), soluble CD27 (sCD27), soluble tumor necrosis factor-alpha receptor type II (sTNFR-II), IgG, IgA, IGE, and IL12 were elevated in HIV-1-infected individuals. The plasma levels of sTNFRII, sCD27, b2m, IL12, and IgG were inversely correlated with numbers of CD41 T-cells, the proportion of naı¨ve (CD45RA1CD271) CD81 T-cells, and the proportion of CD81 T-cells expressing CD28 (CD81CD281) were positively correlated with the proportions of activated (HLADR1CD381) CD41 T-cells, as well as activated (HLADR1CD381) CD81 T-cells. A strong positive correlation was also observed when soluble immune markers were compared to each other. Multivariate regression analyses of soluble markers with numbers of CD41 T-cells showed that sCD27 is the best independent marker for CD41 T-cell decline in the HIV-1-infected Ethiopians. The results indicate that the measurement of soluble immune markers, which is relatively easy to perform, could be a good alternative to the quantification of T-cell subsets for monitoring HIV-1 disease progression in places where there is no facility for flow cytometry measurements. |
| Additional Material | No |
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| Recommended | Yes |
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| Cleaned | Yes |
| Cleaned Format | . csdb |
| RawFormat | . csdb |
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| Date Data Collection Started | 1999-05-29 |
| Date Data Collection End | 1999-08-29 |
| Title | Plasmaa levels of viro-immunological markers in HIV-infected and non -infected Ethiopians: Correlation with cell surface activation markers |
| Data Type | Survey |
| PublicationYear | 2001 |
| SugestedCitation | No sugested citation |
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| Description | This study is a regional representative cross-sectional study conducted among 123 HIV-negative and positive Ethiopians. The study population consisted of three groups of Ethiopians; 52 HIV-negative healthy individuals (designated “HIV2”), 32 HIV-positive individuals with CD4 counts 200/ml and no AIDS-defining conditions (designated “HIV1”), and 39 HIV1 patients with CD4 counts,200/ml and/or exhibiting AIDS-defining conditions based on the WHO staging system for HIV-1 infection and disease (designated “AIDS”). The HIV2 and HIV1 groups are factory workers participating in a prospective cohort study performed by the Ethio-Netherlands AIDS Research Project (ENARP) in Akaki, a village 15 km to the southeast of Addis Ababa, the capital of Ethiopia. Statistical analyses were performed using the STATA program (Stata Corp., Texas, U.S.A.). The level of significance, for the comparison of soluble markers between the three groups, was adjusted using Bonferroni correction (a 5 0.033). The association between several soluble immune markers and CD41 T-cell count was determined using multivariate regression analysis. Correlation coefficients were calculated by spearman’s test. |
| Dataset study design | Longitudinal |
| Date Data Archived | 2020-08-15 |
| Date Data Cataloged | 2020-09-04 |
| Data Generating Unit | HIV and TB Research Directorate |
| URL | https://rtds.ephi.gov.et/public/showdetail/121 |
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Open Access